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Overview of Losartan Carboxylic Acid
Losartan Carboxylic Acid is a key metabolite of Losartan, a widely used medication for the treatment of high blood pressure. The MSDS (Material Safety Data Sheet) for Losartan Carboxylic Acid is essential for understanding its chemical properties, potential hazards, and safe handling procedures.
Importance of MSDS
The MSDS provides crucial information on the composition of Losartan Carboxylic Acid, including its chemical structure, physical properties, and potential health effects. It also outlines safety precautions, emergency procedures, and proper storage and disposal methods.
By consulting the MSDS, individuals working with Losartan Carboxylic Acid can protect themselves from potential hazards, minimize risks of exposure, and ensure compliance with safety regulations.
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C22H23ClN6O |
| Molecular Weight | 422.91 g/mol |
| Appearance | White solid |
| Solubility | Soluble in organic solvents |
Chemical Properties
The chemical properties of Losartan Carboxylic Acid play a crucial role in its function and effectiveness. Understanding these properties is essential for ensuring the proper use of the compound.
Losartan Carboxylic Acid is a white to off-white crystalline powder with a molecular formula of C22H23ClN6O. It has a molecular weight of 422.91 g/mol. The compound is insoluble in water but exhibits solubility in some organic solvents such as methanol and dimethyl sulfoxide.
One of the key chemical properties of Losartan Carboxylic Acid is its role as an angiotensin receptor blocker. It functions by blocking the action of angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure.
Key Chemical Properties:
- Molecular Formula: C22H23ClN6O
- Molecular Weight: 422.91 g/mol
- Solubility: Insoluble in water, soluble in methanol and DMSO
- Mechanism of Action: Angiotensin receptor blocking
Chemical Properties
Losartan carboxylic acid is a white to off-white powder with a molecular formula of C22H25ClN6O. It is sparingly soluble in water but soluble in organic solvents such as acetone and methanol. The compound has a melting point of around 199-201°C.
Acidic Properties
Losartan carboxylic acid is a weak acid with a pKa value of approximately 4.8. This acidic nature plays a crucial role in its pharmacological activity and interactions with other compounds.
- It can form salts with bases to enhance its solubility and stability.
- The acid functionality allows for the formation of various derivatives with modified properties.
Solubility and Stability
Losartan Carboxylic Acid has a moderate solubility in water and shows stability under normal storage conditions. Its solubility can be further enhanced by adjusting the pH of the solution. Due to its stability, Losartan Carboxylic Acid can be stored for extended periods without significant degradation, making it a reliable compound for various applications.
Health and Safety
When handling Losartan Carboxylic Acid, it is important to adhere to strict health and safety guidelines to prevent any potential risks. Here are some key points to consider:
- Always wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat when working with Losartan Carboxylic Acid.
- Avoid inhaling the dust or fumes generated during handling and use the compound in a well-ventilated area.
- Wash hands thoroughly after handling Losartan Carboxylic Acid and avoid any contact with skin or eyes.
- In case of accidental exposure, seek medical attention immediately and bring the Safety Data Sheet (SDS) for Losartan Carboxylic Acid.
- Store Losartan Carboxylic Acid in a cool, dry place away from direct sunlight and sources of ignition.
- Ensure proper labeling of containers to avoid confusion and accidental ingestion.
- Dispose of any waste generated during the handling of Losartan Carboxylic Acid according to local regulations and guidelines.
Health and Safety
Ensuring the health and safety of individuals handling Losartan Carboxylic Acid is paramount to prevent any potential risks. Prior to handling the substance, individuals should be equipped with proper personal protective equipment (PPE) including gloves, lab coat, safety goggles, and a face mask to avoid direct contact or inhalation of the chemical.
It is important to work in a well-ventilated area to minimize exposure to vapors or dust particles. In case of accidental contact with the skin or eyes, rinse immediately with plenty of water and seek medical attention if necessary. Losartan Carboxylic Acid should be stored in a cool, dry place away from direct sunlight and incompatible materials to ensure its stability and prevent any reactions.
Handling and Storage
Proper handling and storage of Losartan Carboxylic Acid are crucial to ensure its efficacy and safety. Here are some guidelines to follow:
Handling:
1. Use appropriate personal protective equipment, including gloves and safety glasses, when handling Losartan Carboxylic Acid.
2. Avoid direct contact with skin, eyes, and clothing. In case of contact, rinse thoroughly with water.
3. Handle Losartan Carboxylic Acid in a well-ventilated area to minimize exposure to fumes.
Storage:
| 1. | Store Losartan Carboxylic Acid in a cool, dry place away from direct sunlight. |
| 2. | Keep the container tightly closed when not in use to prevent contamination. |
| 3. | Avoid storing Losartan Carboxylic Acid near strong acids, bases, or oxidizing agents. |
By following these guidelines for handling and storage, you can ensure the quality and effectiveness of Losartan Carboxylic Acid for your chemical research needs.
Exposure Limits
When working with Losartan Carboxylic Acid, it is crucial to adhere to the recommended exposure limits to ensure safety and prevent any potential health risks. The exposure limits for Losartan Carboxylic Acid are set by regulatory bodies to protect workers from harmful exposure levels.
Occupational Exposure Limits
The Occupational Safety and Health Administration (OSHA) in the United States has established permissible exposure limits (PELs) for Losartan Carboxylic Acid. The current PEL for Losartan Carboxylic Acid is set at X milligrams per cubic meter of air (X mg/m³) as an 8-hour time-weighted average.
It is important for workers to monitor their exposure levels to Losartan Carboxylic Acid and ensure that they are below the specified permissible limits to prevent any adverse health effects.